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The Green Organic Dutchman Holdings Ltd. (the “Company” or “TGOD”) (TSX:TGOD) (US:TGODF), a leading producer of premium certified organic cannabis, and Caliper Foods (formerly Stillwater Foods), a best-in-class provider of water-soluble cannabinoid products, are pleased to unveil the results of a preliminary human pharmacokinetic (“PK“) study of Caliper CBD, Caliper Foods’ proprietary tasteless and odourless water-soluble powder that can be added to almost any food or beverage.

TGOD intends to commercialize organic cannabinoid dissolvables in Canada beginning in December 2019 under the TGOD-Infusers line of premium cannabis products. The Company has already developed novel fast-acting formulations leveraging this technology with its lineup of organic teas, shots, chewables, and ready-to-drink beverages.  In the US, Caliper Foods plans to release Caliper CBD, its own line of precision-dosed CBD dissolvables, this fall.

For this study, half of the participants were administered 30mg of Caliper Foods’ water-soluble CBD powder in 8oz of water while the other half received 30mg of CBD dispersed in MCT oil. Blood samples were drawn at pre-determined times over six hours.  Early data shows that the group that received Caliper CBD demonstrated faster onset within 15 minutes, with higher concentrations achieved at 15 minutes compared to the maximum concentration achieved at 45 min with the CBD in oil formulation, and a 4.5-fold higher observed total bioavailability. The CBD was largely eliminated from the body after about 6 hours for both Caliper CBD and CBD oil subjects, and a more rapid reduction was observed with the Caliper CBD subjects after 45 minutes.

Following this promising initial study, TGOD and Caliper Foods will shortly conduct a confirmatory Clinical Phase 1A PK study that will test the Caliper CBD technology formulated into TGOD’s planned portfolio of products including beverages, teas, Infusers, and capsules. The study will be conducted in collaboration with a leading US academic institution.

“We are delighted with these PK results as they confirm the enhanced bioavailability and consistent absorption rates of our proprietary ingredient technology, which can infuse both CBD and THC. This study confirms that consumers absorb 4.5 times more CBD with Caliper CBD than with CBD in MCT oil,” commented Keith Woelfel, Director of R&D at Caliper Foods.  “Our R&D team is working closely with TGOD on the next phase of the clinical study, which, if it confirms the PK results in additional product forms, will make Caliper Foods’ and TGOD’s product suites highly differentiated in terms of substantiated quality.”

“We are thrilled with the results of this preliminary PK study which demonstrate the consistency and precision of Caliper Foods’ proven proprietary technology which is already available in Colorado and which TGOD will commercialize in Canada. Based on this early data, Caliper CBD provides a higher and faster absorption level when compared with CBD-infused oil, which opens a number of possibilities for both the medical and adult-use markets.  Patients and consumers are increasingly informed and savvy, and we plan to seize on the market demand for organic CBD and THC-infused products backed by data-driven science and clinical evidence,” commented Dr. Rav Kumar, Chief Science Officer of TGOD. “We are enthusiastically awaiting our Clinical Phase 1A PK results in time for Cannabis 2.0 in Canada.”

Caliper Foods’ technology consists of a suite of zero-calorie, fast-acting, water-soluble solutions that can simply and easily infuse cannabinoids into beverages, food, and other consumer goods.  It is formulated to quickly absorb into the bloodstream with a predictable onset and offset, allowing these products to offer a consistent, controlled, and safe experience.  While cannabinoids are naturally fat-soluble and tend to have a bitter taste, Caliper Foods’ ingredient technology eliminates the need for fat molecules to speed absorption or added sugar to mask the bitterness. As a result, it enables healthier, better-tasting products with no additional fat, sugar, or artificial flavours.

TGOD has an exclusive agreement with Caliper Foods to license the Caliper CBD’s ingredient technology, as well as other proprietary beverage and food technologies and formulations related to cannabinoid-infused consumer packaged goods within Canada and distribute to certain international jurisdictions outside of the United States.


SOURCE The Green Organic Dutchman Holdings Ltd.