Researchers at Erasmus University in Rotterdam− the Netherlands have found that a synthetic and fully resorbable TIGR®Matrix surgical mesh (Novus Scientific AB, Uppsala − Sweden) could turn out to be an excellent candidate for reducing the complications that are frequently observed with permanent mesh placement, according to Professor Johan Lange of the Erasmus University in Rotterdam− the Netherlands.
Professor Johan Lange of the Erasmus University said: “Recent research by the R.E.P.A.I.R. study group of the Erasmus University Medical Center has shown that surgical matrices can prevent incisional hernia after laparotomy, but it is well known that permanent meshes can cause severe complications, including seromas, infections, and persistent pain. There is an unmet need for an effective and safer alternative to permanent meshes for several indications in abdominal wall hernia surgery.” A smaller trial in sixteen patients undergoing laparotomy and at risk of incisional hernia reported promising results using onlay TIGR®Matrix placement. The study had a low complication-rate of 12.5 per cent with an exciting efficacy: no cases of incisional hernia occurred.
“Researchers of the R.E.P.A.I.R.-group at the Erasmus University Medical Center are now initiating a large, multicentre, clinical study in 70 patients undergoing midline surgery to investigate the short- and long-term safety and efficacy of onlay TIGR®Matrix surgical mesh,” said lead-investigator of the study Professor Lange. “This study will show if the earlier, positive results with the fully resorbable synthetic mesh can be confirmed.”
Professor Johan Lange has published over 300 articles in peer-reviewed journals, including a recent study comparing sublay and onlay surgical mesh for the prevention of incisional hernia.
